Over the last three months, team eDyNAmiC has been hard at work–publishing in journals of the highest calibre, co-creating plain language summaries to bridge the gap between the public’s understanding of ecDNA and the team’s breakthrough discoveries, and receiving prestigious awards along the way! Below is a summary of team eDyNAmiC’s achievements from November 2024 through February 2025.

A milestone moment for team eDyNAmiC full page feature on the Cancer Grand Challenges site with multiple features

• a deep dive into the three papers published in Nature on November 6, 2024
• a one-on-one interview with Future Leader and co-first author of one of the Nature papers, Chris Bailey, about his motivations for studying medicine, how he came to work on ecDNA, how the paper came together, and the impact of being part of team eDyNAmiC including the importance of working side-by-side patient advocates
• a feature on the fourth Nature paper published by Andrea Ventura on December 18, 2024
• Plain language summaries of each of the four papers co-written and developed by team eDyNAmiC patient advocates and first authors
  • Origins and impact of extrachromosomal DNA
  • Coordinated inheritance of extrachromosomal DNAs in cancer cells
  • Enhancing transcription–replication conflict targets ecDNA-positive cancers
  • Engineered extrachromosomal oncogene amplifications promote tumorigenesis

team eDyNAmiC Future Leader, Grant King, is awarded the prestigious 8-year Hanna Gray fellowship from the Howard Hughes Medical Institute (HHMI). Grant is a postdoc in eDyNAmiC investigator, Harmit Malik’s, lab. Read more about Grant and his work in this news release from the Fred Hutchinson Cancer Center.