The eDyNAmiC team is supported through the Cancer Grand Challenges initiative. Learn more here

Publications

2024

Bei Y, Brame L, Kirchner M, Fritsche-Guenther R, Kunz S, Bhattacharya A, … Henssen AG. (2024). Passenger gene co-amplifications create collateral therapeutic vulnerabilities in cancer. Cancer discovery, doi: 10.1158/2159-8290.cd-23-1189

2023

Chamorro González R, Conrad T, Stöber MC, Xu R, Giurgiu M, Rodriguez-Fos E, … Henssen AG. (2023). Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Nature genetics, 55(5), pp. 880-890. doi: 10.1038/s41588-023-01386-y

Chapman OS, Luebeck J, Sridhar S, Wong IT, Dixit D, Wang S, … Chavez L. (2023). Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. Nature genetics, 55(12), pp. 2189-2199. doi: 10.1038/s41588-023-01551-3

Lazear MR, Remsberg JR, Jaeger MG, Rothamel K, Her HL, DeMeester KE, … Cravatt BF. (2023). Proteomic discovery of chemical probes that perturb protein complexes in human cells. Molecular cell, 83(10), pp. 1725-1742.e12. doi: 10.1016/j.molcel.2023.03.026

Luebeck J, Ng AWT, Galipeau PC, Li X, Sanchez CA, Katz-Summercorn AC, … Mischel PS. (2023). Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus. Nature, 616(7958), pp. 798-805. doi: 10.1038/s41586-023-05937-5

Masui K, Mischel PS. (2023). Metabolic and epigenetic reprogramming in the pathogenesis of glioblastoma: Toward the establishment of “metabolism-based pathology”. Pathology international, 73(11), pp. 533-541. doi: 10.1111/pin.13379

Pusch FF, Dorado Garcia H, Xu R, Gürgen D, Bei Y, Brückner L, … Henssen AG. (2023). Elimusertib has anti-tumor activity in preclinical patient-derived pediatric solid tumor models. Molecular cancer therapeutics, doi: 10.1158/1535-7163.mct-23-0094

Raviram R, Raman A, Preissl S, Ning J, Wu S, Koga T, … Chen C. (2023). Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity. Proceedings of the National Academy of Sciences, (20), doi: 10.1073/pnas.2210991120

Rodriguez-Fos E, Planas-Fèlix M, Burkert M, Puiggròs M, Toedling J, Thiessen N, … Henssen AG. (2023). Mutational topography reflects clinical neuroblastoma heterogeneity. Cell genomics, 3(10), pp. 100402. doi: 10.1016/j.xgen.2023.100402

2022

Bergstrom EN, Luebeck J, Petljak M, Khandekar A, Barnes M, Zhang T, … Alexandrov LB. (2022). Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA. Nature, 602(7897), pp. 510-517. doi: 10.1038/s41586-022-04398-6

Degasperi A, Zou X, Amarante TD, Martinez-Martinez A, Koh GCC, Dias JML, … Nik-Zainal S. (2022). Substitution mutational signatures in whole-genome-sequenced cancers in the UK population. Science (New York, N.Y.), 376(6591), doi: 10.1126/science.abl9283

Hung KL, Luebeck J, Dehkordi SR, Colón CI, Li R, Wong IT, … Chang HY. (2022). Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH. Nature genetics, 54(11), pp. 1746-1754. doi: 10.1038/s41588-022-01190-0

Hung KL, Mischel PS, Chang HY. (2022). Gene regulation on extrachromosomal DNA. Nature structural & molecular biology, 29(8), pp. 736-744. doi: 10.1038/s41594-022-00806-7

Lange JT, Rose JC, Chen CY, Pichugin Y, Xie L, Tang J, … Mischel PS. (2022). The evolutionary dynamics of extrachromosomal DNA in human cancers. Nature genetics, 54(10), pp. 1527-1533. doi: 10.1038/s41588-022-01177-x

Noorani I, Mischel PS, Swanton C. (2022). Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges. Nature reviews. Clinical oncology, 19(11), pp. 733-743. doi: 10.1038/s41571-022-00679-1

Pecorino LT, Verhaak RGW, Henssen A, Mischel PS. (2022). Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance. Biochemical Society transactions, 50(6), pp. 1911-1920. doi: 10.1042/bst20221045

Weiser NE, Hung KL, Chang HY. (2022). Oncogene Convergence in Extrachromosomal DNA Hubs. Cancer discovery, 12(5), pp. 1195-1198. doi: 10.1158/2159-8290.cd-22-0076

Yi E, Chamorro González R, Henssen AG, Verhaak RGW. (2022). Extrachromosomal DNA amplifications in cancer. Nature reviews. Genetics, 23(12), pp. 760-771. doi: 10.1038/s41576-022-00521-5

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