The eDyNAmiC team is supported through the Cancer Grand Challenges initiative. Learn more here

Our Team

 

We are Team eDyNAmiC tackling the extrachromosomal DNA in Cancer Grand Challenge—a task that could revolutionise care for up-to a third of all cancer patients. 

Team eDyNAmiC aims to understand ecDNA, develop strategies, tools, and skills to detect, neutralize, and therapeutically address it. Our team comprises dedicated individuals from diverse scientific and personal backgrounds, each with proven track records of accomplishments and the necessary expertise to confront this unprecedented challenge in cancer.

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Our Team

 

We are Team eDyNAmiC tackling the extrachromosomal DNA in Cancer Grand Challenge—a task that could revolutionise care for up-to a third of all cancer patients. 

Team eDyNAmiC aims to understand ecDNA, develop strategies, tools, and skills to detect, neutralize, and therapeutically address it. Our team comprises dedicated individuals from diverse scientific and personal backgrounds, each with proven track records of accomplishments and the necessary expertise to confront this unprecedented challenge in cancer.

;

Team eDyNAmiC aims to understand the origin, function, and evolution of ecDNA in cancer and to develop novel targeted therapies by leveraging cutting-edge technologies. We also aim to understand the genetic and tissue contexts in which ecDNA arises. We are committed to training the next generation of biomedical revolutionaries, both scientists and clinicians, focused on ecDNA. 

Team eDyNAmiC is poised to deliver new hope through improved diagnostics, new drug targets, and launching points for a transformative new class of medicines to treat patients with ecDNA-driven cancers.

Program Overview

Team eDyNAmiC’s approach is outlined in three Aims, divided into seven Work Packages (WPs). These WPs are interconnected across four Thematic Areas fostering collaboration between investigators, trainees, and patient advocates. This collaboration bridges foundational research to tangible patient outcomes, ultimately striving to improve cancer treatment and overall outcomes for patients.  

Aim 1: To identify the mechanisms involved in generation, function, and maintenance of ecDNA

Aim 2: To determine the role of ecDNA in tumour evolution: understanding and predicting how ecDNA drives cancer heterogeneity, progression, and drug resistance

Aim 3: To identify targetable vulnerabilities of ecDNA-driven cancers to exploit for treatment

Meet the Team

A Global Team

Monje Lab
Mischel Lab
Bafna Lab
Chang Lab
Boeke Lab
Chen Lab
Cravatt Lab
Jamal-Hanjani Lab
Henssen Lab
Huang Lab
Malik Lab
Nik-Zainal Lab
Verhaak Lab
Werner Lab
Ventura Lab
David Arons
Dave Chuter

Shirin Khalili

eDyNAmiC
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