News & Updates
Team eDyNAmiC’s Impact in Year 4
Team eDyNAmiC has made important new mechanistic and clinical discoveries, as well as developed new enabling tools. As Year 4 of our award ends, we are eager to continue the momentum as we enter Year 5. Below, we present 10 areas of high impact. 1. We identified DNA...
Team eDyNAmiC Year 4 Research Retreat & Symposium
Team eDyNAmiC held its annual research retreat and symposium at the Fisher Conference Center at Stanford University November 18-19, 2025. 48 team members from across the US and from the UK and Germany all spent two days together on the Stanford campus; kicked off by...
Congratulations to Team eDyNAmiC Future Leaders
🎉 Congratulations to Team eDyNAmiC Future Leaders on reaching these next milestones in their careers! 🎉 Matthew Jones (Chang and Mischel labs) has been hired as an Assistant Professor at MIT in the Department of Biology with core membership in the Koch Institute for...
Third Quarter News from Team eDyNAmiC
Queen Mary University London (QMUL) features a News story highlighting a recent paper from team eDyNAmiC members - Magnus Haughey and Imran Noorani, two Future Leaders and lead authors, and Ben Werner and Paul Mischel, co-senior authors. Their paper suggests that...
Team eDyNAmiC Team Lead Featured in Science
Team eDyNAmiC Team Lead, Paul Mischel, was featured in a recent issue of Science - Vol 389, Issue 6765, in a News Features story by Elie Dolgin. The story focuses on Paul's career path from starting his lab in the 1990s, his focus on the gene EGFR and its impact on...
Second Quarter of 2025 Wrap-Up: team eDyNAmiC in the News
We’re a bit behind in putting together the Q2 2025 team eDyNAmiC wrap-up but for good reason: we’ve been hard at work the last several months. Here’s a summary of what team eDyNAmiC members have been up to, each link will take you to a page with more information. We...
Team eDyNAmiC Receives Horizon Explorer Recognition Award from Cancer Research Horizons
On July 10, 2025, team eDyNAmiC was honored by Cancer Research Horizons as the 2025 recipient of the Horizon Explorer Recognition Award. The award celebrates team eDyNAmiC's “groundbreaking research redefining our understanding of extrachromosomal DNA (ecDNA) in...
Year 3 In Review: Progress & Impact
Year 3 was a breakthrough year for Team eDyNAmiC. We developed the first mouse genetic model of ecDNA-driven tumorigenesis; gained new insight into ecDNA formation mechanisms; and discovered a critical role for mitotic transcription on ecDNA. We learned how ongoing...
Patient Advocates: Translating the ecDNA Revolution into Widely Accessible Knowledge
At the 2025 Cancer Grand Challenges annual Summit, Team eDyNAmiC Patient Advocates presented a poster that highlights their collaborative model of partnering with investigators and early career researchers to create plain language summaries of team eDyNAmiC's...
Closing the circle: how to multiply genes in cells and mice
Led by the Ventura lab, team eDyNAmiC published a paper in Nature in December 2024. Team eDyNAmiC patient advocates, Katell Maguet and Shirin Khalil, co-developed and wrote in collaboration with the paper’s senior author a plain language summary.. Closing the circle:...
A key molecular “traffic officer” is overworked in ecDNA(+) cancer cells and creates a therapeutic vulnerability
Team eDyNAmiC had three papers published in the November 2024 issue of Nature. Below is the plain language summary of one of the three papers. It has been co-developed by the team eDyNAmiC patient advocates. It was written by Shirin Khalili, Katell Maguet, Dave...
What does the world’s biggest tumor sample collection tell us about ecDNA?
Team eDyNAmiC had three papers published in the November 2024 issue of Nature. Below is the plain language summary of one of the three papers. It has been co-developed by the team eDyNAmiC patient advocates. It was written by Shirin Khalili, Katell Maguet, Dave...
